Instrument Spotlight: PacBio Sequel
GAIN A COMPREHENSIVE VIEW OF GENOMES, TRANSCRIPTOMES, AND EPIGENOMES – Create high-quality whole genome de novo assemblies of eukaryotic organisms – Survey large population cohorts and resolve structural variants – Read full-length transcripts to characterize isoform diversity – Target all variant types across relevant genomic regions – Detect epigenetic modifications simultaneously Get Started: Contact ICBR... Read More
Single Cell Genomics on the 10X Genomics Chromium System
The ICBR and UFHCC have partnered in the acquisition of new cutting-edge technology with the capability of analyzing gene structure and gene activity at the single cell level. The Chromium instrument developed by California-based 10X Genomics inc. provides two unique key technologies to the UF research community. In one application, the instrument uses synthetic gel... Read More
Is Your Monoclonal Antibody Authentic? Confirming Hybridoma Cell Line Identity by IgC cDNA Sequencing
Widespread reports of irreproducibility in health sciences research has prompted the NIH to update new grant application guidelines to include a brief description of methods that will be used to ensure identity and validity of key biological and/or chemical resources used in the proposed study. In this regard there is a significant effort now underway... Read More
Special ICBR Electron Miscroscopy Announcement
The ICBR recently completed several upgrades to the cryoEM facility to enhance the performance of the FEI F20 FEG transmission electron microscope. Specifically, sound dampening walls and a dedicated HVAC system that could deliver sufficient cooling with minimal air current and temperature fluctuations better than +/- 1° F were installed. IFAS and Microbiology and Cell... Read More
ICBR Cytometry Acquires CTAC
In an exciting development for the University of Florida research community, the Cytometry Core at the Interdisciplinary Center for Biotechnology Research, or ICBR, is acquiring the McKnight Brain Institute’s Cell & Tissue Analysis Core, or CTAC. After several fruitful discussions, ICBR and MBI leadership recognized an opportunity to provide even more services to drive research.... Read More
ICBR Bioinformatics contributed to a study on Gestational Hypoxia-Induced Cardiac Anomalies
ICBR Bioinformatics contributed to a study on “Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies” Gestational hypoxia, such as seen in high-altitude pregnancy, has been known to affect cardiac development, yet the incidence and underlying mechanisms are largely unknown.The results of the study provide insights into a common molecular mechanism underlying non-genetic and genetic... Read More